In a foot biopsy, a small sample of the soft tissue affected by a suspicious lesion is removed to evaluate the whole, after local anesthesia. It is then sent to a laboratory for analysis.

In the foot, the most common biopsy technique is a punch biopsy. This involves numbing the surrounding skin of the biopsy site with local anesthetic and then painlessly taking a sample of the skin and soft tissue structures underneath to be sent to a lab to be analyzed.